Thermodynamic vs. Kinetic Control Enables Lewis Acid-Induced Enantioselectivity Reversal Relying on the Same Chiral Source

Paul S. Riehl, Alistair D. Richardson, Tatsuhiro Sakamoto, Jolene P. Reid, and Corinna S. Schindler. Chemrxiv 2020, DOI: 10.26434/chemrxiv.12386081.v2  Link



51) Total synthesis of mycocyclosin and the herqulines

Corinna S. Schindler, Jonathon S. Ryan. Synthesis 2021. doi: 10.1055/a-1403-4312 Link  PDF

50) Synthesis of azetidines via visible light-mediated intermolecular [2+2] photocycloaddition

Marc R. Becker, Emily R. Wearing, and Corinna S. Schindler. Nat. Chem. 2020, 12, 898–905. Link  PDF


Preprint uploaded to Chemrxiv  Link

Behind the paper story  Link

Highlighted by Coote, S. Nat. Chem. 2020, 12, 889–890.  Link

Featured on Synthesis Workshop  Link

Highlighted by Knochel, P.; Djukanovic, D. Synfacts 2020, 16, 1429.  Link

OPRD Items of Interest to Process R&D Chemists and Engineers  Link

49) Superelectrophilic aluminium(iii)–ion pairs promote a distinct reaction path for carbonyl–olefin ring-closing metathesis

Ashlee J. Davis*, Rebecca B. Watson*, Daniel J. Nasrallah, Jessica L. Gomez-Lopez, Corinna S. Schindler. Nat. Catal. 2020, 3, 787–796. *contribued equally Link  PDF

Preprint uploaded to Chemrxiv  Link

Behind the paper story  Link

48) Visible Light-Enabled Paternò-Büchi Reaction via Triplet Energy Transfer for the Synthesis of Oxetanes

Katie A. Rykaczewski, and Corinna S. Schindler. Org. Lett. 2020, 22, 6516–6519. Link  PDF

Preprint uploaded to Chemrxiv  Link

Highlighted by Notizen aus der Chemie. Link

47) Superelectrophilic Fe(III)-Ion Pairs as Stronger Lewis Acid Catalysts for (E)-Selective Intermolecular Carbonyl-Olefin Metathesis.

Haley Albright*, Hannah L. Vonesh*, and Corinna S. Schindler. Org. Lett. 2020, 22, 3155–3160. *contributed equally  Link  PDF

46) High-Throughput Approach toward the Development of a Mizoroki–Heck Reaction To Access Tricyclic Spirolactones

James R. Annand , Paul S. Riehl, Danielle M. Schultz, and Corinna S. Schindler. J. Org. Chem. 2020, 85, 9071–9079.  Link  PDF

45) Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα

James R. Annand, Andrew R. Henderson, Kyle S. Cole, Aaron J. Maurais, Jorge Becerra, Yejun Liu, Eranthie Weerapana, Angela N. Koehler, Anna K. Mapp, and Corinna S. Schindler. ACS Med. Chem. Lett. 2020, 11, 1913–1918.  Link  PDF

44) Synthesis of azetidines by aza Paternò–Büchi reactions

Alistair D. Richardson,* Marc R. Becker,* Corinna S. Schindler. Chem. Sci. 2020, 11, 7553–7561. *contributed equally.  Link  PDF

43) Tetrahydropyridines via FeCl3-Catalyzed Carbonyl–Olefin Metathesis

Katie A. Rykaczewski, Emilia J. Groso, Hannah L. Vonesh, Mario A. Gaviria*, Alistair D. Richardson*, Troy E. Zehnder*, and Corinna S. Schindler. Org. Lett. 2020, 22, 2844–2848. *contributed equally.  Link  PDF

OPRD Items of Interest to Process R&D Chemists and Engineers Link

42) Models for Understanding Divergent Reactivity in Lewis Acid-Catalyzed Transformations of Carbonyls and Olefins

Marc R. Becker*, Jolene P. Reid*, Katie Rykaczewski, Corinna S. Schindler. ACS Catal. 2020, 10, 4387−4397. *contributed equally.  Link  PDF


Preprint uploaded to Chemrxiv on Nov. 25, 2019. Link

41) 8-Step Enantiodivergent Synthesis of (+)- and (-)-Lingzhiol

Paul S. Riehl, Alistair D. Richardson, Tatsuhiro Sakamoto, Corinna S. Schindler. Org. Lett. 2019, 22, 290–294.  Link  PDF

Preprint uploaded to Chemrxiv on Nov. 3, 2019. Link

40) Interrupted Carbonyl‐Alkyne Metathesis

Austin T. McFarlin, Rebecca B. Watson, Troy E. Zehnder, Corinna S. Schindler Adv. Synth. Catal. 2019, 362, 365 –369.  Link  PDF

Special issue in honor of Professor Eric N. Jacobsen's 60th birthday.

39) Functionalized Azetidines Via Visible Light-Enabled Aza Paternò-Büchi Reactions

Marc R. Becker, Alistair D. Richardson, Corinna S. Schindler Nat. Commun. 2019, DOI: 10.1038/s41467-019-13072-x  Link  PDF

Preprint uploaded to Chemrxiv on October 17, 2018. Link

Behind the paper story Link

Top 50 most read Nature Communications articles in 2019 Link

38) Catalytic, Transannular Carbonyl-Olefin Metathesis Reactions

Paul S. Riehl, Daniel J. Nasrallah, Corinna S. Schindler. Chem. Sci. 2019, 10, 10267–10274.  Link  PDF

Preprint uploaded to Chemrxiv on June 27, 2019. Link

37) Lewis Acid-Catalyzed Carbonyl–Olefin Metathesis

Paul S. Riehl, Corinna S. Schindler Trends in Chemistry 2019, 1, 272–273.  Link 

36) Total Syntheses of Herqulines B and C

Xu Zhu*, Christopher C. McAtee*, Corinna S. Schindler J. Am. Chem. Soc. 2019, 141, 3409–3413. *contributed equally  Link  PDF

Preprint uploaded to Chemrxiv on Dec. 24, 2018. Link


Highlighted by Carreira, E. M.; Imhof, M. A. Synfacts 2019, 15, 0224. Link

Highlighted by Synform 2019, A102–A105. Link

35) Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Emilia J. Groso, Corinna S. Schindler. Synthesis 2019, 51, A–O. Link   PDF

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue.


34) Catalytic Carbonyl–Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles

Haley Albright, Paul S. Riehl, Christopher C. McAtee, Jolene P. Reid, Jacob R. Ludwig, Lindsey A. Karp, Paul M. Zimmerman, Matthew S. Sigman, Corinna S. Schindler. J. Am. Chem. Soc. 2019, 141, 1690–1700. Link   PDF

Preprint uploaded to Chemrxiv on Sept. 25, 2018. Link

Highlighted by Knochel, P.; Balkenhohl, M. Synfacts 2019, 15, 0376. Link


33) Carbonyl–Olefin Metathesis for the Synthesis of Cyclic Olefins

Marc R. Becker, Katie A. Rykaczewski, Jacob R. Ludwig, Corinna S. Schindler. Org. Synth. 2018, 95, 472–485.  Link  PDF

32) Beyond olefins: new metathesis directions for synthesis

Marc R. Becker*, Rebecca B. Watson*, Corinna S. Schindler. Chem. Soc. Rev. 2018, 47, 7867–7881. *contributed equally  Link  PDF

31) Interrupted carbonyl-olefin metathesis via oxygen atom transfer

Jacob R. Ludwig, Rebecca B. Watson*, Daniel J. Nasrallah*, Joseph B. Gianino, Paul M. Zimmerman, Ren A. Wiscons, Corinna S. Schindler. Science 2018361, 1363–1369. *contributed equally  Link  PDF

Highlighted by Snieckus, V.; Zhang, Y. Synfacts, 2019, 15, 0025. Link

30) GaCl3-Catalyzed Ring-Opening Carbonyl–Olefin Metathesis

Haley Albright, Hannah L. Vonesh, Marc R. Becker, Brandon W. Alexander, Jacob R. Ludwig, Ren A. Wiscons, Corinna S. Schindler. Org. Lett. 201820, 4954–4958.  Link  PDF

29) Functionalized cyclopentanes via Sc(III)-catalyzed intramolecular enolate alkylation

Christopher C. McAtee, Duncan C. Ellinwood, Rory C. McAtee, Corinna S. Schindler. Tetrahedron 2018, 74, 3306–3313.  Link


Invited contribution to the Tetrahedron Young Investigator Award special issue in honor of Professor Seth Herzon.

28) Scalable Synthesis of Mycocyclosin

Xu Zhu, Christopher C. McAtee, Corinna S. Schindler. Org. Lett. 2018, 20, 2862–2866.  Link  PDF

27) Lewis-Base-Catalyzed Reductive Aldol Reaction To Access Quaternary Carbons

Yvonne C. DePorre, James R. Annand, Sukanta Bar, Corinna S. Schindler. Org. Lett. 2018, 20, 2580–2584.  Link  PDF

26) 3-Aryl-2,5-Dihydropyrroles via Catalytic Carbonyl-Olefin Metathesis

Emilia J. Groso, Alexander N. Golonka, Ryan A. Harding, Brandon W. Alexander, Taylor M. Sodano, Corinna S. Schindler. ACS Catalysis 20188, 2006–2011.  Link  PDF

25) Iron-Catalyzed Synthesis of Tetrahydronaphthalenes via 3,4-Dihydro-2H-pyran Intermediates

Rebecca B. Watson, Corinna S. Schindler. Org. Lett. 2018, 20, 68–71.  Link  PDF

24) Mechanistic Investigations of the Iron(III)-Catalyzed Carbonyl–Olefin Metathesis Reaction

Jacob R. Ludwig, Susan Phan, Christopher C. McAtee, Paul M. Zimmerman, James J. Devery III, Corinna S. Schindler.  J. Am. Chem. Soc. 2017, 139, 10832–10842.  Link  PDF

23) Acid Chlorides as Formal Carbon Dianion Linchpin Reagents in the Aluminum Chloride-Mediated Dieckmann Cyclization of Dicarboxylic Acids

Ahlam M. ArmalySukanta BarCorinna S. SchindlerOrg. Lett. 2017, 19, 3962–3965.  Link  PDF

22) Aluminum Chloride-Mediated Dieckmann Cyclization for the Synthesis of Cyclic 2-Alkyl-1,3-alkanediones: One-Step Synthesis of the Chiloglottones

Ahlam M. Armaly, Sukanta Bar, Corinna S. Schindler. Org. Lett. 2017, 19, 3958–3961.  Link  PDF

21) Lewis Acid Catalyzed Carbonyl–Olefin Metathesis

Jacob R. Ludwig, Corinna S. Schindler. Synlett 201728, 1501–1509.  Link  PDF

20) Iron(III) chloride-catalyzed synthesis of 3-carboxy-2,5-disubstituted furans from γ-alkynyl aryl- and alkylketones

Alexander N. Golonka, Corinna S. Schindler. Tetrahedron 2017, 73, 4109–4114.  Link

Invited contribution to Tetrahedron Symposium "New Advances in Pericyclic Reactions" in print.

19) Catalyst: Sustainable Catalysis

Jacob R. Ludwig, Corinna S. Schindler. Chem 2017, 2, 313–316.  Link

18) Polycyclic aromatic hydrocarbons via iron(III)-catalyzed carbonyl–olefin metathesis

Christopher C. McAtee, Paul S. Riehl, Corinna S. Schindler. J. Am. Chem. Soc. 2017, 139, 2960–2963.  Link  PDF


Highlighted by Swager, T.M.; Dengiz, C. Synfacts 2017, 13, 0481. Link

Featured as part of the 2018 JACS Young Investigator Virtual Issue. Link

17) Iron(III)-catalysed carbonyl–olefin metathesis

Jacob R. Ludwig, Paul M. Zimmerman, Joseph B. Gianino, Corinna S. Schindler. Nature 2016, 533, 374–379.  Link  PDF


Highlighted by Halford, B. Robust route for carbonyl-olefin metathesis. c&en 2016, 94, 8. C&EN News.

Hennessy, E.T.; Jacobsen, E.N. Organometallic Chemistry: A New Metathesis. Nature Chemistry 2016, 8, 741–742. Link

Saá, C. Iron(III)-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis. Angew. Chem. Int. Ed. 2016, 55, 10960–10961. Link

Deska, J. Carbonyl-Olefin-Metathese. Nachrichten aus der Chemie 201664, 604–604. Link

Zeiger, H. Safe and generalizable catalyst for carbonyl-olefin metathesis reaction.

16) Iron(III) Chloride Catalyzed Formation of 3,4-Dihydro-2H-pyrans from α-Alkylated 1,3-Dicarbonyls. Selective Synthesis of α- and β- Lapachone

Rebecca B. Watson, Alexander N. Golonka, Corinna S. Schindler. Org. Lett. 2016, 18, 1310–1313.  Link  PDF

15) Discovery of Novel Synthetic Methodologies and Reagents during Natural Product Synthesis in the Post-Palytoxin Era

Ahlam M. Armaly, Yvonne C. DePorre, Emilia J. Groso, Paul S. Riehl, Corinna S. Schindler. Chem. Rev. 2015, 115, 9232–9276.  Link  PDF

14) New Avenues for the Synthesis of ent-Kaurene Diterpenoids

Paul S. Riehl, Yvonne C. DePorre, Ahlam M. Armaly, Emilia J. Groso, Corinna S. Schindler. Tetrahedron 2015, 71, 6629–6650.  Link

13) Synthesis and biological evaluation of pharbinilic acid and derivatives as NF-kB pathway inhibitors

James R. Annand, Paul A. Bruno, Anna K. Mapp, Corinna S. Schindler. Chem. Comm. 201551, 8990–8993.  Link  PDF

Before Michigan:

12) Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-Bond Donor and Lewis Base

Yongho Park, Corinna S. Schindler, Eric N. Jacobsen. J. Am. Chem. Soc. 2016, 138, 14848–14851.


11) Access to the Aeruginosin Serine Protease Inhibitors through the Nucleophilic Opening of an Oxabicyclo- (2.2.1)heptane: Total Synthesis of Microcin SF608

Stefan Diethelm, Corinna S. Schindler, Erick M. Carreira.  Chem. Eur. J. 2014, 20, 6071–6080.

10) Photoredox Activation and Anion Binding Catalysis in the Dual Catalytic Enantioselective Synthesis of β-Amino Esters

Giulia Bergonzini, Corinna S. Schindler, Carl-Johan Wallentin, Eric N. Jacobsen, Corey R. J. Stephenson. Chem. Sci. 2014, 5, 112–116.

9) A New Twist on Cooperative Catalysis

Corinna S. Schindler, Eric N. Jacobsen. Science 2013, 340, 1052–1053.

8) Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site

Corinna S. Schindler, Louis Bertschi, Erick M. Carreira. Angew. Chem. Int. Ed. 2010, 49, 9229–9232.


7) Facile Formation of N-Acyl-oxazolidinone Derivatives Using Acid Fluorides

Corinna S. Schindler, Patrik M. Forster, Erick M. Carreira. Org. Lett. 2010, 12, 4102–4105.


6) Synthesis of Microcin SF608 through Nucleophilic Opening of an Oxabicyclo(2.2.1)heptene

Stefan Diethelm, Corinna S. Schindler, Erick M. Carreira. Org. Lett. 2010, 12, 3950–3953.


5) Rapid Formation of Complexity in the Total Synthesis of Natural Products Enabled by Oxabicyclo(2.2.1)hep-tane building blocks

Corinna S. Schindler, Erick M. Carreira. Chem. Soc. Rev. 2009, 38, 3222–3241.


4) Nucleophilic Ring Opening of Oxabicyclic Ring Systems

Corinna S. Schindler, Stefan Diethelm, Erick M. Carreira. Angew. Chem. Int. Ed. 2009, 48, 6296–6299.


3) Enantioselective Synthesis of the Core of Bayaside, Suomilide and Spumigin HKVV

Corinna S. Schindler, Corey R. J. Stephenson, Erick M. Carreira. Angew. Chem. Int. Ed. 2008, 47, 8852–8855.


2) Total Synthesis of Marinomycins A-C and of Their Monomeric Counterparts Monomarinomycin A and iso-Monomarinomycin A

K. C. Nicolaou, Andrea L. Nold, Robert R. Milburn, Corinna S. Schindler, Kevin P. Cole, Junichiro Yamaguchi. J. Am. Chem. Soc. 2007, 129, 1760–1768.


1) Total Synthesis of Marinomycins A-C

K. C. Nicolaou, Andrea L. Nold, Robert R. Milburn, Corinna S. Schindler. Angew. Chem. Int. Ed. 2006, 45, 6527–6532.

© 2018 by Corinna S. Schindler. All Rights Reserved.